VION Food Boxtel will take over the activities of VION Food Helmond. The Helmond location will be closed with about 130 job cuts.
The company said in a statement the changes are part of a complete restructure to restore financial results in the pork market.
It said it will try to re-assign staff internally but this depends on a redundancy scheme, which needs to be agreed upon.
In 2011, VION's turnover was €9.5 billion. In early 2013, the firm employed over 21,000 staff.
It is not a listed company and has a single, agricultural shareholder, the Zuidelijke Land- en Tuinbouworganisatie (ZLTO), an agricultural and horticultural association with some 18,000 members.